WCN26-5830 A TRANSLATIONAL FRAMEWORK TO PREDICT CLINICAL RESPONSES TO APRIL BLOCKADE FOR DEVELOPMENT OF JADE101, AN ANTI-APRIL MONOCLONAL ANTIBODY IN IgAN

Key Points

• The central aim is to develop a framework to predict clinical responses to an anti-April monoclonal antibody for IgAN.
• Translational framework development based on protein trafficking and folding analysis.
• Assessment of allele-dependent effectiveness of PBA.
• Evaluation of personalized treatment strategies for patients with hypomorphic mutations.
• Promising evidence indicates personalized treatment can benefit patients with specific mutations.
• Further clinical investigations are warranted to validate preclinical findings.

Abstract