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March 28, 2026Journal of Applied Physiology

Muscle Atrophy After ACL Reconstruction Involves Molecular Mechanisms Beyond Unloading

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Authors

AKAlexander R. KeebleSGSara Gonzalez-VelezNTNicholas T. Thomas

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Overview

Comparative analysis shows unique gene expression after ACLR influencing muscle recovery, suggesting specific interventions may be needed.

Key Points

  • This research aims to unveil the molecular mechanisms involved in muscle atrophy after ACL reconstruction compared to limb unloading.
  • Utilized publicly-available RNA-seq datasets from vastus lateralis muscle biopsies post-ACLR and unilateral lower limb suspension (ULLS)
  • Compared transcriptomic responses between ACLR and ULLS with matched control limbs
  • Employed bioinformatic analyses to identify differentially expressed genes (DEGs).
  • Identified over 1,000 more DEGs after ACLR compared to ULLS
  • Only 16% of DEGs were common between ACLR and ULLS
  • Notable reductions in extracellular matrix remodeling and increased expression of denervation-responsive genes observed post-ACLR.

Cite This Study

Keeble et al. (2026) studied this question.

synapsesocial.com/papers/69c771988bbfbc51511e1922https://doi.org/10.1152/japplphysiol.00088.2026
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