Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway

Puntos clave

• The aim is to explore how allyl isothiocyanate (AITC) affects collagen-induced arthritis (CIA) through mast cell targeting and Pim1 pathway activation.
• Examined the role of mast cells in AITC treatment.
• Analyzed the impact of AITC on collagen-induced arthritis progression.
• Investigated the Pim1 signaling pathway in mast cell activation.
• AITC significantly suppresses mast cell activation in CIA.
• Pim1-related signaling appears essential for AITC's effectiveness.
• Mast cells are identified as a vital target for AITC in inflammatory response.

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