Eliminating cancer stem cells can inhibit progression of residual hepatocellular carcinoma after radiofrequency ablation

Key Points

• The aim is to explore how eliminating cancer stem cells can slow down the growth of leftover liver cancer after treatment.
• Utilized radiofrequency ablation (RFA) as the primary treatment method.
• Assessed the effects of an ERK inhibitor combined with Sal on cancer cell behavior.
• Measured changes in cell proliferation, migration, and stemness in residual tumors.
• Combining the ERK inhibitor with Sal significantly reduced cell proliferation.
• The treatment decreased migration of cancer cells in residual tumors.
• Reduction in stemness markers suggests inhibited tumor progression.

Abstract