Expediated synthesis of N-acyl-N-alkyl sulfonamide probes for protein proximity labelling

Key Points

• This research aims to streamline the synthesis of N-acyl-N-alkyl sulfonamide probes for efficient protein labeling.
• Developed an expedited synthetic route for NASAs.
• Focused on site-selective protein labeling via proximity-mediated reactions.
• Assessed the efficiency of the new synthesis method.
• The new synthesis method reduced the complexity of probe production.
• Demonstrated improved efficacy in labeling proteins compared to traditional methods.
• Contributed to the practical applications in biochemical research and labeling techniques.

Abstract