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March 29, 2026Frontiers in Cell and Developmental BiologyOpen Access

A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity

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Authors

ESEric SeidelCologne Excellence Cluster on Cellular Stress Responses in Aging Associated DiseasesEIE. Yaren ItakFMFabienne MüllerCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

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Overview

Explores how cell growth dynamics affect ferroptosis sensitivity in cellular populations, indicating important biological interactions.

Key Points

  • The research aims to understand how cell proliferation and reactive oxygen species interact to influence ferroptosis sensitivity.
  • Utilized live-cell imaging and ROS tracing to observe cellular dynamics.
  • Examined effects of cell density on proliferation rates and ROS levels.
  • Implemented experimental interventions to manipulate lipid hydroperoxide levels and ROS production.
  • Developed a mathematical model to predict population fate in relation to ROS and proliferation.
  • Identified a feedback loop between cell population growth and ferroptosis sensitivity.
  • Demonstrated that lower ROS levels at high cell density lead to reduced ferroptosis.
  • Characterized two steady states: ferroptosis-insensitive state with low ROS and slow growth, and a sensitive state with high ROS and rapid growth.
  • Validated the feedback mechanism experimentally through specific interventions.

Cite This Study

Seidel et al. (2026) studied this question.

synapsesocial.com/papers/69c8c0b0de0f0f753b39b8b7https://doi.org/10.3389/fcell.2026.1756238
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