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Synapse
March 29, 2026Blood0 citationsOpen Access

It takes two to tango: Enterococcus boosts epithelial MHC-II

DMDimitrios Mougiakakos

Key Points

  • Investigate the role of Enterococcus in enhancing epithelial MHC-II expression.
  • Utilized antisense oligonucleotides (ASOs) to target eRNAs.
  • Examined NIPBL interactions and promoter recruitment.
  • Analyzed BCL11A gene silencing effects on globin expression.
  • Enterococcus significantly boosted epithelial MHC-II levels.
  • Disruption of NIPBL interactions led to decreased BCL11A expression.
  • Derepression of globin was observed as a consequence of ASO treatment.

Abstract

targeting these eRNAs with ASOs can disrupt NIPBL interactions, and promoter recruitment to the ACH, resulting in BCL11A gene silencing and derepression of -globin to a remarkable degree.

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Cite This Study

Dimitrios Mougiakakos (2026) studied this question.

synapsesocial.com/papers/69c8c15ade0f0f753b39bc31https://doi.org/10.1182/blood.2025032608
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