A VE/VCO2 slope over 31 optimally predicted one-year major adverse cardiovascular events, occurring in 39.8% of young heart failure patients with moderately reduced exercise capacity.
Does the VE/VCO2 slope predict 1-year major adverse cardiovascular events in young heart failure patients with moderately reduced exercise capacity?
In young heart failure patients with moderately reduced exercise capacity, a VE/VCO2 slope >31 is a strong independent predictor of 1-year MACE and may help identify patients needing early referral for advanced therapies like LVAD or heart transplantation.
Absolute Event Rate: 0% vs 0%
Background: Exercise capacity, evaluated using cardiopulmonary exercise testing (CPET), is an important prognostic factor in ambulatory heart failure (HF) patients.However, interpreting the results of CPET in young, ambulatory HF patients who tend to J o u r n a l P r e -p r o o f be optimistic about their prognosis is complicated.This study aimed to assess the clinical impact of CPET parameters in predicting the prognosis of young, ambulatory HF patients.Methods: This single-center retrospective observational study targeted young (12 mL/kg/min.The primary endpoint was occurrence of major adverse cardiovascular events (MACE), such as death, admission for HF, and fatal arrhythmia, within 1 year after CPET.Results: A total of 113 patients (median age, 43 35-47 years) were enrolled: of these, 45 (39.8%) experienced MACE (death, n = 2; admission for HF, n = 35; fatal arrhythmia, n = 8).Multivariate Cox regression analysis demonstrated age, plasma brain natriuretic peptide level, serum creatinine level, and ventilatory efficiency (VE/VCO2 slope) were associated with the occurrence of MACE within 1 year after CPET.Receiver operating characteristic curve analysis revealed a VE/VCO2 slope of 31 was the optimal cutoff value for predicting prognosis.Conclusions: Nearly 40% of young (12 mL/kg/min) experienced MACE within 1 year after CPET.Among these patients, those with a VE/VCO2 slope >31 may warrant earlier consideration for left ventricular assist devices or heart transplantation.
Komeyama et al. (Sun,) reported a other. A VE/VCO2 slope over 31 optimally predicted one-year major adverse cardiovascular events, occurring in 39.8% of young heart failure patients with moderately reduced exercise capacity.