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March 29, 2026IEEE Transactions on Neural Systems and Rehabilitation Engineering0 citationsOpen Access

Localizing tDCS Targets in Drug-Resistant Epilepsy with EEG Source Networks

Localizing Target for Transcranial Direct Current Stimulation in Drug-Resistant Epilepsy using Dynamic EEG Source Network

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Authors

YLYao LiuYHYuxuan HanCLChunsheng Li

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Overview

This analysis demonstrates effective localization of tDCS targets in drug-resistant epilepsy, suggesting improved treatment outcomes.

Key Points

  • The aim is to create a non-invasive method to accurately localize targets for transcranial direct current stimulation in patients with drug-resistant epilepsy.
  • Utilized interictal scalp EEG to estimate brain connectivity in the source space.
  • Developed a dynamic EEG source network based on neural mass models for target localization.
  • Employed SimNIBS simulations to optimize target location for tDCS.
  • Used intracranial EEG data from 18 patients to validate the proposed procedure.
  • The localized target matched with the resected brain area in 80% of seizure-free patients.
  • Only 37.5% of non-seizure-free patients had the localized target match.
  • Significant reduction in seizure likelihood observed with cathodal stimulation at the target compared to non-target locations.
  • Highlighting the critical role of selecting low-noise segments for improved performance.
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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69c8c15ade0f0f753b39bd24https://doi.org/10.1109/tnsre.2026.3677891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Opportunities for the future of transcranial magnetic stimulation and epilepsy2026
  2. 2Transcranial electrical stimulation during functional magnetic resonance imaging in patients with genetic generalized epilepsy: a pilot and feasibility study2024 · 1 citations
  3. 3Bridging computational and clinical strategies for presurgical identification of epileptogenic networks2026
  4. 4Individualized Target Selection of Closed-loop Electrical Stimulation for the Treatment of Spontaneous Temporal Lobe Epilepsy.2025
  5. 5Bridging Computational and Clinical Strategies to Improve Presurgical Identification of Epileptogenic Networks2025