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March 29, 2026Circulation Population Health and Outcomes0 citationsOpen Access

Cardiovascular Conditions and Symptoms in Deaths Attributed to Acute Stimulant Toxicity

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PCPhillip O. CoffinVMVanessa M. McMahanYCYi-Shin Grace Chang

Key Points

  • This research examines the relationship between cardiovascular conditions and deaths attributed to acute stimulant toxicity.
  • Analyzed cardiovascular conditions and symptoms in deaths related to stimulants.
  • Compared cases involving stimulants alone to those involving stimulants with opioids like fentanyl.
  • Identified patterns in cardiovascular disease prevalence among stimulant decedents.
  • Cardiovascular conditions were frequently observed in stimulant-related deaths.
  • Higher prevalence of symptoms was noted in deaths from stimulants without opioids than with fentanyl.
  • Implying that stimulant users may require targeted interventions for cardiovascular disease prevention.

Abstract

Premortem cardiovascular conditions and symptoms were common among stimulant decedents and were more prevalent among deaths attributed to stimulants without opioids compared with those involving fentanyl. In addition to opioid overdose prevention efforts, people who use stimulants might benefit from aggressive prevention and treatment of cardiovascular disease.

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Cite This Study

Coffin et al. (2026) studied this question.

synapsesocial.com/papers/69c8c22cde0f0f753b39c652https://doi.org/10.1161/circoutcomes.125.012683
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