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March 29, 2026Journal of Nanobiotechnology2 citationsOpen Access

Injectable Nanocomposite Hydrogel for Infection-Resistant Diabetic Wound Healing

Injectable ROS-scavenging and NIR-responsive nanocomposite hydrogel for staphylococcus aureus-infected diabetic wound healing

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Authors

MCMing CaiZLZhao LiuXSXun Sun

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Overview

Injectable hydrogel demonstrates improved wound healing in diabetic models infected with Staphylococcus aureus, indicating effective treatment.

Key Points

  • The research aims to develop a hydrogel that can treat chronic diabetic wounds impacted by infections and oxidative stress.
  • Synthesized hydrogel using dynamic boronate-ester crosslinking of poly(vinyl alcohol) and bis-boronic acid linker.
  • Incorporated PGS/MoS₂ nanocomposites to provide photothermal and photodynamic therapy.
  • Conducted in vitro tests to assess ROS scavenging, hyperthermic response, and antibacterial activity.
  • Evaluated wound healing efficacy in a diabetic mouse model.
  • The hydrogel effectively scavenged ROS and induced mild hyperthermia (~48 °C) under NIR light.
  • Demonstrated significant antibacterial activity against Staphylococcus aureus.
  • Achieved 46.7% residual wound area at day 7, compared to 66.5–92.4% in controls.
  • Almost complete wound healing was noted by day 14, with reduced bacterial load and inflammation.

Cite This Study

Cai et al. (2026) studied this question.

synapsesocial.com/papers/69c8c25dde0f0f753b39cb07https://doi.org/10.1186/s12951-026-04306-4
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