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March 29, 2026Liver International0 citations

Metallothionein Safeguards Hepatic Zn‐Fe Homeostasis and Restrains Yap‐Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis

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YFYinrui FengZZZixuan ZhouYXYing Xiao

Key Points

  • The research investigates the role of metallothionein in maintaining trace-metal balance and its influence on Yap signaling to prevent liver fibrosis.
  • Examined the role of metallothionein in hepatocytes.
  • Analyzed zinc and iron homeostasis in liver tissue.
  • Assessed Yap signaling pathways in liver fibrosis models.
  • Metallothionein effectively maintains zinc and iron levels in the liver.
  • Enhancing metallothionein activity reduces Yap-driven iron overload.
  • Combining zinc supplementation with Yap inhibition shows promise in reducing liver fibrosis.

Abstract

These findings reveal MT as a key hepatocyte integrator of trace-metal homeostasis and Yap signalling and suggest that therapeutic strategies enhancing MT activity or combining Zn supplementation with Yap inhibition may offer new avenues to prevent or reverse chronic liver fibrosis.

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69c8c28cde0f0f753b39cea7https://doi.org/10.1111/liv.70624
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