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March 29, 2026Psychological Medicine0 citationsOpen Access

The causal impact of older siblings’ academic achievement on younger siblings’ risk for drug use disorder: instrumental variable and propensity score analyses

KKK S KendlerHOHenrik OhlssonAFAbigail A. Fagan

Key Points

  • To explore the causal relationship between older siblings' academic achievement and younger siblings' risk for drug use disorder.
  • Utilized instrumental variable analysis to assess causal impacts.
  • Applied propensity score methods to control for confounding variables.
  • Focused on sibling pairs for a comparative analysis.
  • Identified a significant causal link between low academic achievement in older siblings and increased drug use disorder risk in younger siblings.
  • Observed stronger effects in closely aged sibling pairs, particularly among male-male pairs.
  • Suggested that improving older siblings' academic achievement could indirectly benefit younger siblings by reducing drug use risk.

Abstract

Findings from two causal inference approaches support a largely causal link between low AA in an older sibling and increased DUD risk in younger siblings. Stronger effects in close-aged and male-male pairs further support this conclusion. Interventions to improve AA in older siblings may yield indirect preventive benefits for younger siblings.

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Cite This Study

Kendler et al. (2026) studied this question.

synapsesocial.com/papers/69c8c2b8de0f0f753b39d26bhttps://doi.org/10.1017/s0033291726103729
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