Sequential Microsatellite Instability and Next-Generation Sequencing Screening for Lynch Syndrome in Patients with Colorectal Cancer

Key Points

• This research aims to investigate the role of microsatellite instability and next-generation sequencing in diagnosing Lynch syndrome among colorectal cancer patients.
• Conducted genetic screening for microsatellite instability in colorectal cancer samples.
• Utilized next-generation sequencing to identify potential Lynch syndrome biomarkers.
• Analyzed the correlation between microsatellite instability status and sequencing results.
• Identified significant instances of microsatellite instability in a subset of colorectal cancer cases.
• Demonstrated that next-generation sequencing can effectively screen for genetic markers of Lynch syndrome.
• Highlighted the potential for genomic screening to guide treatment decisions in colorectal cancer.