Cardiac magnetic resonance feature tracking demonstrated high diagnostic efficacy in differentiating NDLVC patients with reduced versus preserved LVEF, with 3D global circumferential strain yielding an AUC of 0.981.
Observational (n=90)
No
Does cardiac magnetic resonance feature tracking (CMR-FT) accurately differentiate between reduced and preserved LVEF in patients with non-dilated left ventricular cardiomyopathy?
CMR-FT 2D and 3D strain parameters provide high diagnostic efficacy in differentiating between reduced and preserved ejection fraction in patients with non-dilated left ventricular cardiomyopathy.
Effect estimate: AUC 0.981 (95% CI 0.956-1.000)
To investigate the diagnostic value of cardiac magnetic resonance imaging feature tracking (CMR-FT) in evaluating patients with non-dilated left ventricular cardiomyopathy (NDLVC) and either reduced or preserved left ventricular ejection fraction (LVEF). This retrospective study enrolled 60 patients with NDLVC, including 30 with reduced LVEF (NDLVC-rLVEF, LVEF < 50%) and 30 with preserved LVEF (NDLVC-pLVEF, LVEF ≥ 50%), along with 30 healthy controls. Using the CVI42 post-processing software, conventional left ventricular functional parameters and 2D/3D global strain parameters were obtained, including global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS). Group differences in these parameters were analyzed. The diagnostic efficacy of strain parameters in NDLVC patients with reduced LVEF was evaluated using receiver operating characteristic (ROC) curve analysis. (1) Compared to the NDLVC-pLVEF group, the NDLVC-rLVEF group was older (P < 0.05) and had a higher prevalence of hyperlipidemia and alcohol consumption history. (2) Compared to the control group, the NDLVC-pLVEF group showed a significant increase in LV mass at ED (P < 0.05). Compared to the NDLVC-pLVEF group, the NDLVC-rLVEF group exhibited significantly increased left ventricular end-systolic volume (LVESV) and LV mass at ED (P < 0.05), while left ventricular stroke volume (LVSV), left ventricular cardiac output (LVCO), left ventricular ejection fraction (LVEF), absolute values of GRS (2D/3D), GCS (2D/3D), GLS (2D/3D) were significantly reduced (P < 0.05). (3) ROC curve analysis revealed that the AUC values for GRS (2D), GCS (2D), GLS (2D), GRS (3D), GCS (3D), and GLS (3D) in distinguishing the NDLVC-rLVEF group from NDLVC-pLVEF group were 0.980, 0.974, 0.941, 0.908, 0.981, and 0.843, respectively. CMR-FT technique demonstrates significant diagnostic value in differentiating NDLVC patients with both reduced and preserved LVEF. Both 2D and 3D strain parameters exhibit high diagnostic efficacy.
Yan et al. (2026) conducted an observational in Non-dilated left ventricular cardiomyopathy (NDLVC) (n=90). Cardiac magnetic resonance feature tracking (CMR-FT) vs. NDLVC with preserved LVEF and healthy controls was evaluated on Diagnostic efficacy (AUC) of 3D global circumferential strain (GCS) in differentiating NDLVC-rLVEF from NDLVC-pLVEF (AUC 0.981, 95% CI 0.956-1.000). Cardiac magnetic resonance feature tracking demonstrated high diagnostic efficacy in differentiating NDLVC patients with reduced versus preserved LVEF, with 3D global circumferential strain yielding an AUC of 0.981.