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March 29, 2026Open Access

Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval

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Authors

MCManuela CostaDPDaniel Pacheco-EstefanAGAntonio Gil-Nagel

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Overview

Direct recordings show hippocampal gamma activity correlates with aversive memory retrieval in humans, suggesting neural mechanisms for memory recall.

Key Points

  • This study aims to understand the role of hippocampal gamma activity in the retrieval of aversive memories encoded by the amygdala.
  • Direct recordings from the human amygdala and hippocampus
  • Analysis of gamma activity during memory encoding and retrieval
  • Comparison of encoding patterns with retrieval patterns
  • Increased hippocampal gamma activity observed for correctly remembered aversive scenes
  • Patterns of high amplitude gamma activity in the amygdala were reactivated in the hippocampus during retrieval
  • Hippocampal gamma patterns showed representational similarity with amygdala encoding activity

Cite This Study

Costa et al. (2025) studied this question.

synapsesocial.com/papers/69c8c336de0f0f753b39de44https://doi.org/10.5167/uzh-433444
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success2025
  2. 2Adaptive shifts in amygdala–hippocampal theta coupling govern aversive learning and extinction2026
  3. 3Adaptive shifts in amygdala–hippocampal theta coupling govern aversive learning and extinction2026 · 1 citations
  4. 4Hippocampal Reactivation Trades Episodic Detail for Semantic Gist in Human Memory2026
  5. 5Engram reactivation mimics cellular signatures of fear2024 · 18 citations