PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 29, 2026Inhalation Toxicology0 citations

PET/CT imaging-based quantification of respiratory tract deposition of small- and large-particle aerosols versus intranasal bolus in rodents

View Full Paper
JBJeremy A. BoydstonHYH. J. YangSMSteve Mazur

Key Points

  • To examine how different particle sizes of aerosols deposit in the respiratory tract of rodents using PET/CT imaging.
  • Used PET/CT imaging for quantification of particle deposition
  • Compared large- and small-particle aerosols against intranasal bolus of FDG
  • Analyzed regional distribution of particle deposition in the lungs
  • Found an inverse relationship between particle size and pulmonary deposition
  • Intranasal bolus showed deposition patterns similar to large-particle aerosols
  • Study raises concerns about aerosol exposure methods compared to intranasal administration

Abstract

PET/CT imaging-based quantification enabled novel characterization of particle deposition in rodents and supports an inverse relationship between aerodynamic particle size and pulmonary deposition. The regional distribution of intranasal bolus administered FDG more closely resembled large-particle aerosols than small-particle aerosols. These findings may aid in understanding the infectivity and pathogenicity of bioaerosols based on particle size and raise concern about substituting intranasal administration for aerosol exposure.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Boydston et al. (2026) studied this question.

synapsesocial.com/papers/69c8c336de0f0f753b39de5fhttps://doi.org/10.1080/08958378.2026.2648617
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters2024 · 23 citations
  2. 2SARS-CoV-2 infection results in a unique lung proteome long after virus resolution in the hamster2024 · 4 citations
  3. 3Modeling the Disease Course ofZaire ebolavirusInfection in the Outbred Guinea Pig2015 · 47 citations
  4. 4Exposure of guinea pigs to Rickettsia rickettsii by aerosol, nasal, conjunctival, gastric, and subcutaneous routes and protection afforded by an experimental vaccine1979 · 17 citations
  5. 5Mucociliary clearance: pathophysiological aspects2013 · 208 citations