Renal denervation significantly reduced the diurnal polyuria index (0.182 vs. 0.338) and renal angiotensinogen levels (1.070 vs. 1.595) compared to sham in a mouse model of nocturnal polyuria.
Does renal denervation reduce intrarenal renin-angiotensin system activity and salt-induced nocturnal polyuria in a mouse model?
In a mouse model, renal denervation suppressed intrarenal renin-angiotensin system activity and improved salt-induced nocturnal polyuria, suggesting a potential therapeutic mechanism targeting sympathetic overactivity.
Absolute Event Rate: 0.182% vs 0.338%
p-value: p=<0.01
Purpose: This study was aimed at assessing the effects of cerebral sympathetic nervous system activity and renal denervation (RD) on the intrarenal renin-angiotensin system (RAS) and salt-induced nocturnal polyuria (NP).Methods: To establish a mouse model, NP was induced by Nω-nitro-L-arginine methyl ester and a high-salt diet. Mice were subjected to dietary, pharmacological, and RD interventions, with blood pressure, urine output, renal norepinephrine, kidney protein expression, and c-Fos positive cells in the hypothalamic paraventricular nucleus (PVN) assessed using standardized physiological, biochemical, and histological methods.Results: Renal angiotensinogen (AGT) and PVN c-Fos were significantly increased in NP model mice, indicating sympathetic activation. RD lowered renal AGT and the diurnal polyuria index versus sham (1.070±0.091 vs. 1.595±0.136 arbitrary units, P<0.01; 0.182±0.018 vs. 0.338±0.021, P<0.01).Conclusions: Cerebral sympathetic activation may promote intrarenal RAS activity and salt-induced NP; therefore, RD may be a potential therapeutic strategy to improve NP.
Tsujimura et al. (2026) studied Nocturnal polyuria. Renal denervation vs. Sham surgery was evaluated on Diurnal polyuria index (DPi) (p=<0.01). Renal denervation significantly reduced the diurnal polyuria index (0.182 vs. 0.338) and renal angiotensinogen levels (1.070 vs. 1.595) compared to sham in a mouse model of nocturnal polyuria.