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March 29, 2026The Oncologist0 citationsOpen Access

Primary brainstem lymphoma: clinical characteristics, treatment methods, and prognostic factors of 56 patients

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WGWenhui GuoLDLing DuanSYSheng Yin

Key Points

  • The research aims to analyze clinical features, treatment methods, and survival prognostic factors in patients with primary brainstem lymphoma.
  • Analyzed clinical characteristics of 56 patients with primary brainstem lymphoma.
  • Evaluated treatment methods including high-dose methotrexate chemotherapy and radiotherapy.
  • Assessed survival outcomes and overall response rates to different treatments.
  • Patients with brainstem lymphoma showed worse survival rates compared to those with tumors in other locations.
  • High-dose methotrexate chemotherapy achieved a high overall response rate.
  • Radiotherapy was identified as an important salvage treatment for reducing brainstem lesions rapidly.

Abstract

PBSL has worse survival outcomes compared to tumors in other sites. HD-MTX chemotherapy remains effective, achieving a high ORR. Radiotherapy is an important salvage alternative for rapidly reducing brainstem lesions.

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Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/69c8c35cde0f0f753b39e137https://doi.org/10.1093/oncolo/oyaf105
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