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March 29, 2026DevelopmentOpen Access

CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis

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Authors

FMFelix MaRZRu ZhouMRMatthew Rosin

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Overview

Demonstrates that macrophages and osteoclasts are essential for craniofacial development, suggesting critical roles in morphogenesis.

Key Points

  • This research aims to investigate the roles of CSF1R+ macrophages and osteoclasts in craniofacial morphogenesis during fetal development.
  • Used PLX5622 to inhibit CSF1R signaling in prenatal subjects.
  • Assessed proliferation and differentiation of macrophages and osteoclasts.
  • Examined craniofacial structures and neural crest development following treatment.
  • Achieved approximately 50% depletion of CSF1R+ macrophages and complete loss of osteoclasts.
  • Observed skull doming and cranial suture impairments.
  • Disruptions noted in the development of premaxilla, mandible, ear ossicles, palate, and cranial base.
  • Altered cytokine and chemokine signaling correlated with impaired neural crest proliferation.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/69c8c384de0f0f753b39e56ahttps://doi.org/10.1242/dev.205423
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis2025
  2. 2CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis2026
  3. 3Expression and Role of Colony Stimulating Factor 1 Receptor During Odontogenesis2026
  4. 4Expression and Role of Colony Stimulating Factor 1 Receptor During Odontogenesis2026
  5. 5Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer2024 · 4 citations