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March 29, 2026Organic Letters

Methyl Formate Meets Water: Phosphine-Free Mn(I) Catalysis for Chemoselective Olefin & Carbonyl Hydrogenation

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Authors

DMDivya MahapatraASAnirban SauSDS. N. Das

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Overview

Lab experiments demonstrate efficient hydrogenation of olefins and carbonyl groups using Mn(I) in water, suggesting a new catalytic approach.

Key Points

  • The aim is to develop a phosphine-free catalytic system using Mn(I) for chemoselective hydrogenation in water.
  • Utilized a Mn(I)-bisNHC system for catalysis.
  • Investigated methyl formate dehydrogenation in aqueous conditions.
  • Combined experimental techniques with DFT (density functional theory) studies.
  • Achieved chemoselective transfer hydrogenation of olefins and carbonyls.
  • Identified base-assisted Mn-H formation as a key mechanism.
  • Demonstrated substrate-driven electronic effects governing selectivity.

Cite This Study

Mahapatra et al. (2026) studied this question.

synapsesocial.com/papers/69c8c384de0f0f753b39e667https://doi.org/10.1021/acs.orglett.6c00484
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