To verify the efficacy of artificial hypobiosis as a method for the preventive protection of living organisms against ionizing radiation, the experimental study was conducted. The study involved male rats, which were divided into two groups: the experimental group and the control group. Rats in the experimental group underwent induction of artificial hypobiosis through intramuscular injection of the alpha-methyldopa (CAS: 555-30-6). Both groups of rats underwent simulated acute radiation exposure. The radiation was delivered using a “GUT-200M” gamma-ray irradiator, powered by “GIK-7-4” cobalt-60 sources. The absorbed dose administered was 9.5 ± 0.1 Gray (Gy). Afterward, the rats body weights were monitored daily, and the timing of weight loss cessation and weight gain initiation, as well as death, were recorded. The findings of the study revealed that the mortality of 50% of the laboratory rats subjected to artificial hypobiosis occurred 1.4 times later compared to the control group.; Artificial hypobiosis has been shown to prevent the death of approximately 50% of animals exposed to a lethal dose of ionizing radiation equivalent to 9.5 Gy (100% mortality in the control group). In surviving animals weight gain has been observed beginning on the 18th day of the study.
Makarov et al. (2025) studied this question.