The research aims to create novel lipid nanoparticle (LNP) formulations that do not contain polyethylene glycol (PEG) and utilize sugar-based surfactants.
Formulation of LNPs using sugar-based surfactants.
Evaluation of drug delivery efficiency.
Assessment of biocompatibility compared to traditional PEG-based formulations.
The new sugar-based LNP formulations showed higher drug encapsulation efficiency.
Improved biocompatibility was found in comparison to PEG-containing LNPs.
Enhanced stability of the novel formulations was observed.
Abstract
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