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March 30, 2026Open Access

Longitudinal association between early-life famine exposure and risk of microvascular complications of type 2 diabetes in adulthood: A retrospective cohort in Tianjin, China.

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Authors

XCXiaocui ChengQWQi WuWZWei Zhao

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Overview

Retrospective cohort shows increased risk of microvascular complications in type 2 diabetes with early-life famine exposure, indicating implications for obesity and hypertension management.

Key Points

  • To explore the link between early-life famine exposure and the risk of microvascular complications in adulthood for individuals with type 2 diabetes.
  • Conducted a retrospective cohort study in Tianjin, China
  • Analyzed data on early-life famine exposure and prevalence of microvascular complications in adults with T2D
  • Evaluated associations with variables like hypertension and obesity
  • Exposure to famine in early life is associated with increased risks of microvascular complications, including DMC, DR, and DKD in adults with T2D.
  • The risk of diabetic retinopathy (DR) is particularly higher in those with hypertension.
  • Diabetic kidney disease (DKD) shows a stronger association with early-life famine exposure among individuals with hypertension or both general and abdominal obesity.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69c9c51bf8fdd13afe0bd069https://doi.org/10.6133/apjcn.202604_35(2).0006
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