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The Prevalence of Central Nervous System-Active Polypharmacy in US Nursing Homes. | Synapse

March 30, 2026

The Prevalence of Central Nervous System-Active Polypharmacy in US Nursing Homes.

Key Points

To assess the prevalence of CNS-active polypharmacy in nursing homes and its association with psychiatric comorbidity.
Cross-sectional analysis of nursing home residents in the US
Assessment of medication use and psychiatric conditions
Data collection on resident demographics and pain levels
CNS polypharmacy was prevalent among nursing home residents
Higher rates noted in individuals with psychiatric comorbidity
Need for deprescribing strategies to reduce associated risks

Abstract

CNS polypharmacy was common in US nursing homes, especially among residents with psychiatric comorbidity and in pain. These findings underscore the need for deprescribing strategies and nonpharmacologic interventions to mitigate risks associated with CNS polypharmacy.

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Authors

H

Heeyoon Jung

S

Shao‐Hsien Liu

A

Anne L Hume

Actions

Institutions

University of Massachusetts Chan Medical School

University of Rhode Island

References and Citations

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Cite this study

Jung et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69c9c51bf8fdd13afe0bd1b4 — DOI: https://doi.org/10.1016/j.jamda.2026.106178