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March 30, 2026Clinical & Experimental Allergy0 citationsOpen Access

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

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HMHazel MarriottAAAdil AdatiaSMSubhabrata Moitra

Key Points

  • This research aims to explore the impact of tezepelumab on cytokine levels in patients with severe asthma.
  • Evaluation of alarmin cytokine levels in nasal epithelial cells after tezepelumab treatment.
  • Assessment of severe asthma patients' response to biologic therapy.
  • Tezepelumab treatment resulted in reduced alarmin cytokine levels in nasal epithelial cells.

Abstract

Summary Nasal epithelial cell alarmin cytokine levels are reduced in patients with severe asthma following tezepelumab. This is the first report showing nasal alarmin cytokine protein expression depletion following biologics.

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Cite This Study

Marriott et al. (2026) studied this question.

synapsesocial.com/papers/69c9c553f8fdd13afe0bd27fhttps://doi.org/10.1111/cea.70294
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