What question did this study set out to answer?

To evaluate the effects of low-intensity pulsed ultrasound on neuroinflammation and recovery after spinal cord injury.

March 30, 2026Open Access

Low‐Intensity Pulsed Ultrasound Promotes Spinal Cord Injury Recovery by Regulating Microglia‐Mediated Neuroinflammation

Puntos clave

To evaluate the effects of low-intensity pulsed ultrasound on neuroinflammation and recovery after spinal cord injury.
Utilized low-intensity pulsed ultrasound (LIPUS) in spinal cord injury models.
Analyzed microglial activation and neuroinflammatory markers post-treatment.
Investigated signaling pathways including NOD-like receptor and IL-17.
LIPUS significantly reduced neuroinflammation in spinal cord injury models.
Improved neurological function was observed following LIPUS treatment.
Downregulation of CXCR2 and modulation of hub genes were noted.

Resumen

LIPUS effectively alleviates neuroinflammation after SCI and promotes neurological function recovery by regulating microglia-mediated neuroinflammation, whose mechanism is associated with the modulation of NOD-like receptor, IL-17 signaling pathways and the downregulation of hub genes such as CXCR2. This study provides a scientific basis for the clinical application of LIPUS in SCI treatment and a theoretical foundation for exploring multi-modal therapeutic strategies combining LIPUS with other therapies.

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