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March 30, 2026Journal of Women s Health0 citations

The Influence of Personal and Family Support on Maternal Cardiovascular Health: Insights from a TriNetX Study

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OTOluwaremilekun Tolu-AkinnawoAAAnderson AnuforoIBIkeoluwapo Kendra Bolakale-Rufai

Key Points

  • This study aims to explore the impact of personal and family support on maternal cardiovascular health after pregnancy.
  • Examined postpartum cardiovascular outcomes using TriNetX network.
  • Compared women with poor support (Cohort 1) to matched controls with adequate support (Cohort 2).
  • Defined support issues using ICD-10 Z63 codes from 9 months before to 1 year after delivery.
  • Applied propensity score matching for analysis of outcomes within 1 year.
  • Inadequate support linked to 5 times higher odds of major adverse cardiac and cerebrovascular events.
  • Increased odds of acute kidney injury found among women with poor support.
  • No significant differences noted for myocardial infarction, stroke, heart failure, or peripartum cardiomyopathy.

Abstract

Background: Maternal cardiovascular health during and after pregnancy is shaped by biological, behavioral, and social factors. Inadequate personal and family support remains underexplored as a driver of postpartum cardiovascular risk. Understanding this relationship is vital for developing targeted interventions. Methods: Using the TriNetX U.S. Collaborative Network, we examined postpartum cardiovascular outcomes among women aged 15–60 years with documented problems in personal or family support (poor support cohort, Cohort 1) compared with matched controls (Cohort 2) with no support-related Z63 codes. Personal/family support concerns were defined using ICD-10 Z63. x codes recorded 9 months before to 1 year after delivery or postpartum encounters. Propensity score matching was applied. Outcomes were assessed within 1 year. Results: After matching ( n = 10,669 per cohort), inadequate support was associated with higher odds of major adverse cardiac and cerebrovascular events (odd ratio OR 5.012, 95% CI: 3.461–7.257) and acute kidney injury (OR: 1.438, 95% CI: 1.015–2.039). No significant differences were observed for myocardial infarction, stroke, heart failure, or peripartum cardiomyopathy. Conclusion: Poor personal and family support is associated with adverse maternal cardiovascular outcomes. Caution is warranted in interpreting mortality due to potential misclassification. Integrating psychosocial support into postpartum care may reduce risk and improve maternal outcomes.

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Cite This Study

Tolu-Akinnawo et al. (2026) studied this question.

synapsesocial.com/papers/69c9c5a4f8fdd13afe0bd906https://doi.org/10.1177/15409996261437018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1To Assess the Impact of the Quality and Level of Family Support to Pregnant Women on Maternal and Fetal Outcomes2024
  2. 2Association of pre-pregnancy cardiovascular risk factor burden with adverse maternal and offspring outcomes2021 · 40 citations
  3. 3Postnatal experiences of women with cardiac conditions: a systematic review and meta-synthesis2025 · 2 citations
  4. 4Preconception risk and promotive factors of postpartum social support: A multidecade prospective cohort study.2026 · 1 citations
  5. 5Maternal relationship during adolescence predicts cardiovascular disease risk in adulthood.2016 · 15 citations