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March 30, 2026SHILAP Revista de lepidopterologíaOpen Access

NPM1-Mutated Acute Myeloid Leukemia with Uterine Myeloid Sarcoma: A Diagnostic Challenge

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Authors

DTDaiana TUNARUGCGabriela Diana CANTORIDIon Dumitru

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Overview

Case report highlights diagnostic uncertainty in acute myeloid leukemia with coagulopathy, implicating immunophenotyping and molecular testing.

Key Points

  • To illustrate the diagnostic challenges of NPM1-mutated acute myeloid leukemia presenting with features of acute promyelocytic leukemia.
  • Case report of a 56-year-old patient presenting with severe hemorrhagic syndrome and leukocytosis.
  • Peripheral blood smear and immunophenotyping were used to assess leukemic cells.
  • Molecular testing confirmed NPM1 mutation while identifying extramedullary myeloid sarcoma.
  • Increased white blood cell count and specific immunophenotype indicated acute myeloid leukemia.
  • Presence of disseminated intravascular coagulation added diagnostic complexity.
  • Diagnostic features often overlap with those of acute promyelocytic leukemia, causing uncertainty.

Cite This Study

TUNARU et al. (2026) studied this question.

synapsesocial.com/papers/69c9c5c5f8fdd13afe0bddf6https://doi.org/10.59854/dhrrh.2026.4.1.29
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