Antioxidant Activity and DFT Studies of Ethyl 2-(2-((6-Methyl-4-Oxo-4h-Chromen-3-Yl) Methylene)hydrazinyl)thiazole-4-Carboxylate

ABSTRACT. The microwave-assisted improved synthesis of ethyl 2-(2-((6-methyl-4-oxo-4H-chromen-3-yl)methylene)hydrazinyl)thiazole-4-carboxylate is described. The antioxidant potential of the target compound was evaluated using spectrophotometric methods, including the DPPH• and ABTS•⁺ radical scavenging assays, as well as three additional electron-transfer assays employing metal-based oxidizing agents. The title compound exhibited good antioxidant activity compared to reference antioxidants. For the title compound theoretical quantum chemical (DFT) calculations were performed.