Advanced cardiac fibrosis combined with positive tenascin-C expression was associated with significantly worse event-free survival (P<0.0001) in patients with peripartum cardiomyopathy.
Observational
No
Do advanced myocardial fibrosis and Tenascin-C expression predict poor clinical outcomes in patients with peripartum cardiomyopathy?
Patients clinically diagnosed with peripartum cardiomyopathy (PPCM) who underwent right ventricular endomyocardial biopsy
Advanced myocardial fibrosis (>10%) and positive Tenascin-C (TNC) expression on endomyocardial biopsy
Mild myocardial fibrosis and negative Tenascin-C (TNC) expression
Composite of cardiac death, left ventricular assist device (LVAD) implantation, and/or heart transplantationhard clinical
Advanced myocardial fibrosis and positive Tenascin-C expression on endomyocardial biopsy are significant predictors of poor long-term prognosis in patients with peripartum cardiomyopathy.
Background: Peripartum cardiomyopathy (PPCM) is a potentially life-threatening condition. The histological characteristics of PPCM as risk factors for poor outcomes have not been thoroughly investigated. This study evaluated the pathological findings of PPCM, with a particular focus on inflammatory factors such as tenascin-C (TNC) and interleukin-6, which may predict left ventricular dysfunction and the prognosis of PPCM.
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Kisaki Amemiya
Junko Nakashima
Keiko Ohta-Ogo
Circulation Journal
National Cerebral and Cardiovascular Center
Chikamori Hospital
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Amemiya 등(금요일)은 분만기 심근병증(n=27)을 대상으로 관찰 연구를 수행하였습니다. 고도 심장 섬유화 및 Tenascin-C (TNC) 발현군과 경증 심장 섬유화 및 TNC 음성 발현군 간에 심장 사망, 좌심실 보조장치(LVAD) 삽입, 및/또는 심장 이식의 복합 결과가 평가되었으며(p=<0.0001), 고도 심장 섬유화와 양성 tenascin-C 발현의 병합은 분만기 심근병증 환자에서 유의하게 불량한 무사건 생존율과 관련이 있었습니다(P<0.0001).
www.synapsesocial.com/papers/69ca134b883daed6ee0952cf — DOI: https://doi.org/10.1253/circj.cj-25-0768