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March 31, 2026Journal Of Clinical Periodontology1 citationsOpen Access

Dental Biofilm–Induced Gingivitis in Children and Adolescents Without Known Systemic Involvement: A Systematic Review

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GTGeorgios TsilingaridisNTNitesh TewariKSKyriaki Seremidi

Key Points

  • To synthesize evidence on gingival diseases in children and adolescents without systemic conditions.
  • Conducted a systematic review following PRISMA guidelines.
  • Included data from PubMed Central, Scopus, EMBASE, and LILACS.
  • Reviewed clinical trials and observational studies for children under 18 years.
  • Narrowed 33,180 studies to 269 focusing on biofilm-induced gingivitis.
  • Dental biofilm-induced gingivitis was found in 52% of subjects.
  • Poorer oral health-related quality of life was associated with gingivitis.
  • Key determinants included socioeconomic status, oral hygiene, and pubertal changes.
  • Effective management involves supervised toothbrushing, fluoridated toothpaste, and education.

Abstract

ABSTRACT Aim To synthesize evidence on gingival diseases and conditions in children and adolescents (< 18 years) without known systemic disorder involvement, focusing on their distribution, aetiology, diagnosis, management and oral health–related quality of life (OHRQoL). Materials and Methods A systematic review was carried out following PRISMA guidelines, including PubMed Central, Scopus, EMBASE and LILACS, up to January 2025. Clinical trials and observational studies addressing gingival diseases or conditions in healthy individuals under 18 years were included. Results The search identified 33,180 studies. Title and abstract screening narrowed these to 2264, of which 433 were full‐text‐reviewed. Ultimately, 269 studies, all restricted to biofilm‐induced gingivitis, were included. Considerable heterogeneity was observed in diagnostic criteria and study quality. Dental biofilm–induced gingivitis was common (52%) and associated with poorer OHRQoL. Key determinants for gingival inflammation included socioeconomic status, oral hygiene behaviours, pubertal changes and malocclusion. Based on current evidence, effective management of gingivitis in children should combine supervised toothbrushing with a fluoridated toothpaste and school‐ or caregiver‐based oral health education. Adjunctive use of chlorhexidine may provide additional benefit in certain clinical situations. Conclusion Dental biofilm–induced gingivitis is frequent among children and adolescents and influenced by numerous determinants. Prevention and treatment should emphasise accessible, behaviour‐focused and education‐based strategies for biofilm control.

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Cite This Study

Tsilingaridis et al. (2026) studied this question.

synapsesocial.com/papers/69cb64f0e6a8c024954b8f76https://doi.org/10.1111/jcpe.70122
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