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March 31, 2026Journal of Obstetrics Gynecology and Cancer ResearchOpen Access

Synergistic Effects of IL-16 and KRAS in Endometriosis with Emphasis on Oxidative Stress

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Authors

DSDeepthi SudharmaNMNatrajan MuninathanASArumugam Suresh

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Overview

Case-control study shows IL-16 and KRAS influence oxidative stress in endometriosis, suggesting new targets for therapy.

Key Points

  • This study aims to explore the roles of IL-16 and KRAS gene expression in endometriosis and their relationship with oxidative stress markers.
  • Conducted a case-control study with 300 subjects, including 150 endometriosis cases and 150 healthy controls.
  • Analyzed IL-16 and KRAS gene expression via real-time PCR.
  • Measured oxidative stress markers like Superoxide Dismutase, glutathione peroxidase, and vitamin C, along with IL-6 levels.
  • IL-16 and KRAS gene expression were significantly higher in endometriosis cases compared to controls, with KRAS as an independent predictor (P=0.002).
  • Oxidative stress markers showed decreased levels of SOD and glutathione peroxidase, and lower vitamin C in endometriosis cases.
  • Elevated IL-6 levels (>5.57 pg/mL, OR=7.91, P=0.032) linked to increased inflammation and oxidative damage.

Cite This Study

Sudharma et al. (2026) studied this question.

synapsesocial.com/papers/69cb6541e6a8c024954b969ahttps://doi.org/10.24200/jogcr.11.4.358
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