Silicon Rhodamine-based Fluorescent Probes for Monitoring Mitochondrial Viscosity Dynamics during Mitophagy

Key Points

• The aim is to develop fluorescent probes that monitor mitochondrial inner membrane viscosity during mitophagy in real-time.
• Design and synthesize silicon rhodamine-based fluorescent probes.
• Utilize advanced imaging techniques to visualize mitochondrial viscosity.
• Conduct experiments to correlate viscosity changes with mitophagy activity.
• Successfully developed probes that can measure changes in mitochondrial viscosity.
• Observed significant viscosity alterations during mitophagy.
• Validated that viscosity dynamics can serve as an indicator of mitochondrial health.