Organ-Specific Changes on the Background of Metabolic Disorders in Obese Rats

The aim of the work was to study specific changes in internal organs against the background of metabolic disorders in rats with experimental obesity. Experimental obesity was initiated by feeding rats a high-fat diet for 12 weeks. The diet of the experimental animals included standard feed enriched with lard. A histological examination of the internal organs and a biochemical blood test were performed. After 12 weeks of a high-fat diet, the rats showed an increase in body weight and metabolic disorders, which consisted in a significant increase in blood levels of glucose, triglycerides, total cholesterol, and renal metabolites. Organ-specific changes were characterized by the development of fatty liver and kidney degeneration, adaptive reactions in the small intestine, and structural changes in the vascular system.