A Review on Pharmacosomes - Vesicular Drug Delivery System

Pharmacosomes are an emerging class of vesicular drug delivery systems developed to enhance the therapeutic performance of pharmaceutical compounds. These systems are formed through the covalent linkage of drug molecules with phospholipids, resulting in amphiphilic complexes that can spontaneously organize into vesicular structures. This characteristic enables efficient delivery of both hydrophilic and lipophilic drugs. Compared to conventional delivery approaches, pharmacosomes offer improved drug stability, higher loading efficiency, and reduced risk of drug leakage. The phospholipid component plays a crucial role in protecting the drug from degradation and promoting cellular uptake, thereby supporting targeted delivery. In addition, these systems can be engineered to provide controlled and sustained drug release, which contributes to reduced side effects and enhanced patient compliance. However, certain limitations, including formulation complexity, stability issues during storage, and possible immunological responses, need to be addressed. Continuous research efforts aimed at optimizing formulation strategies and improving scalability are expected to expand the application of pharmacosomes in advanced drug delivery.