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April 1, 2026Current Issues in Molecular BiologyOpen Access

The Role of the SOS Response in the Adaptation of Pseudomonas aeruginosa

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Authors

EZEmilia ZarembskaAPAnna Pietruczuk-PadzikMWMałgorzata Wrzosek

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Overview

This review highlights how SOS response modulates antibiotic adaptation in Pseudomonas aeruginosa, suggesting implications for treatment strategies.

Key Points

  • This review aims to explore the role of the SOS response in the adaptive mechanisms of Pseudomonas aeruginosa during antibiotic exposure.
  • Reviewed experimental and clinical studies
  • Focused on SOS response to fluoroquinolones and genotoxic agents
  • Investigated RecA-dependent signaling pathways
  • SOS activation was consistently induced by fluoroquinolone exposure
  • Findings do not support a major role for SOS activation in long-term resistance evolution
  • Relationship between SOS and mutagenesis is variable, involving different mechanisms

Cite This Study

Zarembska et al. (2026) studied this question.

synapsesocial.com/papers/69ccb71716edfba7beb88e03https://doi.org/10.3390/cimb48040355
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