Two types of experiments are used to study RNA-chromatin interactions: a search for the interactome of individual RNAs (“one-to-all” or OTA) and a genome-wide search for contacts of all RNAs (“all-to-all” or ATA). A comparative analysis of ATA and OTA data revealed their fundamental differences in resolution, completeness, and specificity. OTA data provide high resolution (~1000 bp) and reproducibility (~90%), serving as a “gold standard”. In contrast, ATA data have lower resolution (~5000 bp), and their reproducibility (
Ryabykh et al. (Wed,) studied this question.