Ethnopharmacological relevance: Aloe vera (Aloe barbadensis Miller) is one of the mostwidely recognized medicinal plants, documented in traditional systems across Asia, Africa,and the Mediterranean. It has been used in Ayurveda, Traditional Chinese Medicine, Unani,and Arabian medicine for skin, gastrointestinal, and systemic disorders.Aim of the review: To synthesize ethnomedicinal knowledge, phytochemistry,pharmacological activities, and clinical evidence of Aloe vera with emphasis on itsethnopharmacological significance and therapeutic potential.Materials and methods: Literature was collected from PubMed, Scopus, Google Scholar,and ethnopharmacological texts, integrating traditional knowledge with modernpharmacological data.Results: More than 75 phytoconstituents, including polysaccharides (acemannan,glucomannan), anthraquinones (aloin, emodin), sterols (lupeol, campesterol), enzymes,vitamins, and minerals, have been identified. These contribute to pharmacological activitiessuch as wound healing, anti-inflammatory, antimicrobial, immunomodulatory, andantioxidant effects. Clinical trials support the efficacy of Aloe gel in burns, oral lichenplanus, and dental healing, while evidence in psoriasis and diabetes is inconsistent.Conclusions: Aloe vera exemplifies the link between traditional ethnomedicine and modernpharmacology. While ethnomedical claims are validated by preclinical and clinical data,future research must focus on extract standardization, mechanistic studies, and large-scale
Yadav et al. (Mon,) studied this question.