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April 1, 2026The Japanese Journal of Gastroenterological Surgery0 citationsOpen Access

A Case of Primary Hepatic Squamous Cell Carcinoma Producing Granulocyte Colony Stimulating Factor with Five-Year Disease-Free Survival

YNYukihisa NAKAZAWATSTakumi SAKAKIBARAKIKosuke Ikeda

Key Points

  • The aim is to discuss a rare case of hepatic squamous cell carcinoma producing G-CSF with favorable outcomes.
  • Clinical examination and imaging diagnostics led to the identification of a liver tumor.
  • Biopsy confirmed the diagnosis of squamous cell carcinoma.
  • Tumor resection was performed due to rapid tumor growth and elevated G-CSF levels.
  • Tumor reduced from 7.5 cm post-resection with normal G-CSF and leukocyte levels achieved.
  • Five years post-surgery, no signs of tumor recurrence were observed.
  • Only three similar cases of G-CSF producing hepatic squamous cell carcinoma have been reported in Japan.

Abstract

症例は78歳の男性で，ネフローゼ症候群などで当院へ通院中，1か月前より継続する食欲不振と発熱を主訴に受診した．血液生化学検査で白血球数の増加と，CTにて肝内に長径4.5 cmの腫瘤を認め，肝膿瘍の疑いで入院となった．造影CTと造影MRIで肝悪性腫瘍と診断し，腫瘍生検を行い扁平上皮癌と診断された．入院後，全身状態のさらなる悪化と白血球の増加，腫瘍の急激な増大を認めた．Granulocyte colony stimulating factor（以下，G-CSFと略記）産生腫瘍で，極めて悪性度の高い腫瘍と考え早急に肝左葉切除術を施行した．術前に測定した血液生化学検査でG-CSF値が異常高値であった．切除標本での腫瘍最大径は7.5 cm，病理検査ではG-CSF産生性が証明され，G-CSF産生肝扁平上皮癌と診断され，腺癌成分は認めなかった．術後速やかに全身状態の改善を認め，白血球数・G-CSF値は正常化した．術後5年経過した現在，画像上で再発の兆候は認めていない．G-CSF産生肝扁平上皮癌本邦報告例は3例しかなく，貴重な症例と思われた．

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Cite This Study

NAKAZAWA et al. (2026) studied this question.

synapsesocial.com/papers/69cd79e15652765b073a6ac5https://doi.org/10.5833/jjgs.2024.0128
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