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Synapse
April 1, 2026Neurological SciencesOpen Access

Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches

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Authors

ASAli K. SaadNANadia Akawi

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Overview

Literature review explores genetic causes and treatment variability in monogenic epilepsy, suggesting improved diagnostic strategies.

Key Points

  • The aim is to explore the genetic basis, classification, and treatment strategies for monogenic epilepsy disorders.
  • Reviewed recent studies and databases on monogenic epilepsies.
  • Evaluated classification systems and genetic landscapes.
  • Analyzed treatment approaches based on genetic aetiologies.
  • Identified around 2000 genes linked to seizures and epilepsy.
  • Revealed significant locus heterogeneity and phenotypic variability.
  • Emphasized the need for personalized treatment strategies based on molecular aetiology.

Cite This Study

Saad et al. (2026) studied this question.

synapsesocial.com/papers/69cd79e15652765b073a6c1ahttps://doi.org/10.1007/s10072-026-08936-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity2026
  2. 2Advances in pharmacogenomics: optimizing antiepileptic drug therapy for drug-resistant epilepsy2024 · 2 citations
  3. 3The Clinical and Genetic Landscape of a French Multicenter Cohort of 2563 Epilepsy Patients Referred for Genetic Diagnosis2025 · 8 citations
  4. 4Genetic–Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies2026 · 3 citations
  5. 5Unraveling the Complexity of Seizures and Epilepsies: a Multifaceted Approach to Classification, Syndromes, Causes, and Integrated Therapies2024