A biodegradable semi-rigid mitral valve annuloplasty ring was successfully developed using a blend of poly L-lactic acid, poly ɛ-caprolactone, and polyglycolic acid for pediatric patients.
Does a biodegradable semi-rigid mitral valve annuloplasty ring reduce regurgitation fraction in an in vitro porcine mitral valve regurgitation model?
A novel biodegradable semi-rigid annuloplasty ring designed for children successfully reduced regurgitation in an in vitro porcine mitral valve model.
Descriptive information has indicated unsatisfactory outcomes associated with mitral valve plasty in the case of pediatric patients. Conversely, favorable outcomes have been consistently reported in adult cases, primarily attributed to the feasibility of prosthetic annuloplasty rings. Due to this notable distinction, we aimed to address the specific needs of small children by developing a semi-rigid annuloplasty ring for the mitral valve, employing biodegradable polymers. The expectation is that this approach would involve the gradual degradation and absorption of the developed semi-rigid annuloplasty ring, coinciding with the remodeling of the mitral annulus. The inner support medium was crafted from sutures composed of a blend of poly L-lactic acid and poly ɛ-caprolactone copolymer, mixed at a molar ratio of 3:1. Subsequently, this material was bundled together and coiled around a saddle-shaped mold rod. Following heat processing, a reinforced saddle-shaped rod with a diameter of 0.6mm was successfully created. The external cuff utilized a blade weaving technique made of polyglycolic acid, facilitating the smooth insertion of needles. A blade material was woven using 16 sets of polyglycolic acid sutures (size 50D), resulting in an internal diameter of 2mm and an area density of 0.55mg/mm³. The internal rod was inserted within the polyglycolic acid blade, and both ends were subjected to heat processing at a temperature of 230°C for 10 seconds to prevent fraying. This device holds the potential to offer a solution for enhancing the outcomes of pediatric mitral valve plasty, and address the current challenges associated with unsatisfactory results in this patient population. Additionally, its applicability to adult patients could potentially eliminate the requirement for lifelong anticoagulation therapy.
誠 et al. (Fri,) conducted a other in Pediatric mitral valve disease. Biodegradable semi-rigid mitral valve annuloplasty ring was evaluated. A biodegradable semi-rigid mitral valve annuloplasty ring was successfully developed using a blend of poly L-lactic acid, poly ɛ-caprolactone, and polyglycolic acid for pediatric patients.