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April 1, 20260 citationsOpen Access

Contribution of Adequate Preoperative Circulatory Management to Uneventful Perioperative Course of Transurethral Resection of a Bladder Tumor for a Patient with Hypertrophic Obstructive Cardiomyopathy

HKHaruka KimuraTSTakayuki SuganoMUMasashi Uzawa

Key Result

Preoperative pharmacological therapy with carvedilol and cibenzoline reduced the resting LVOT gradient from 81 mmHg to 43 mmHg, enabling an uneventful transurethral resection of a bladder tumor.

Key Points

  • To evaluate the role of preoperative circulatory management in the perioperative safety of bladder tumor surgery for a patient with hypertrophic obstructive cardiomyopathy.
  • Case report of a 67-year-old man with hypertrophic obstructive cardiomyopathy scheduled for TUR-Bt.
  • Initial evaluation revealed a left ventricular outflow tract gradient of 81 mmHg, leading to surgery postponement.
  • Preoperative pharmacological therapy was initiated using carvedilol and cibenzoline to reduce LVOT gradient.
  • Spinal anesthesia combined with obturator nerve block was chosen for anesthetic management during surgery.
  • Continuous monitoring of arterial blood pressure took place throughout the procedure.
  • The initial LVOT gradient decreased from 81 mmHg to 41 mmHg after pharmacological therapy.
  • The TUR-Bt proceeded without complications after rescheduling.
  • Postoperative intervention included percutaneous transluminal septal myocardial ablation, reducing the LVOT gradient to 3 mmHg.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
1 patient (67-year-old man) with hypertrophic obstructive cardiomyopathy (HOCM) and bladder cancer scheduled for transurethral resection of bladder tumor (TUR-Bt).
I
Intervention
Preoperative pharmacological therapy with carvedilol (up to 15 mg/day) and cibenzoline (up to 450 mg/day) followed by spinal anesthesia for TUR-Bt, and later percutaneous transluminal septal myocardial ablation (PTSMA).
O
Outcome
Perioperative course and left ventricular outflow tract (LVOT) gradient

Adequate preoperative pharmacological control of the LVOT gradient using carvedilol and cibenzoline can facilitate safe noncardiac surgery under spinal anesthesia in patients with severe HOCM.

Limitations

  • Single case report
  • Precise evaluation of the patient's performance status was impossible because the patient avoided exercise load

Abstract

In noncardiac surgery for patients with hypertrophic obstructive cardiomyopathy (HOCM), there is no safety criterion of the left ventricular outflow tract (LVOT) gradient and no standardized anesthetic management. Transurethral resection of bladder tumor (TUR-Bt) was scheduled for a 67-year-old man with HOCM. Because the LVOT gradient at rest was 81 mmHg, we postponed the surgery and initiated preoperative pharmacological therapy for HOCM using carvedilol and cibenzoline. The LVOT gradient at rest decreased to 41 mmHg, and then TUR-Bt was rescheduled. Spinal anesthesia in combination with obturator nerve block was chosen for anesthetic management, and arterial blood pressure was continuously monitored. The surgery and postoperative course were uneventful. After the surgery, the patient underwent percutaneous transluminal septal myocardial ablation (PTSMA), by which the LVOT gradient at rest decreased to 3 mmHg. We suppose that adequate control of the LVOT gradient is essential in the management of noncardiac surgery for patients with HOCM.

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Cite This Study

Kimura et al. (2019) conducted a case report in Hypertrophic Obstructive Cardiomyopathy and Bladder Tumor (n=1). Preoperative pharmacological therapy (carvedilol and cibenzoline) was evaluated on Resting left ventricular outflow tract (LVOT) gradient. Preoperative pharmacological therapy with carvedilol and cibenzoline reduced the resting LVOT gradient from 81 mmHg to 43 mmHg, enabling an uneventful transurethral resection of a bladder tumor.

synapsesocial.com/papers/69cd7b475652765b073a9283https://doi.org/10.14994/tohojmed.2018-010
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