April 1, 2026European Heart Journal - Valvular and Structural Heart DiseaseOpen Access
Clinical characteristics, treatment strategies, and outcomes of patients with aortic valve infective endocarditis with and without aortic root abscess: Insights from the NIDUS registry
Registry-based cohort study examines treatment and outcomes in infective endocarditis patients, indicating significant mortality differences based on aortic root abscess status.
Key Points
This research aims to compare clinical characteristics, treatment strategies, and outcomes of patients with aortic valve infective endocarditis, focusing on those with and without aortic root abscesses.
Conducted a nationwide cohort study using the National Danish Endocarditis Study registry.
Included all patients with aortic valve endocarditis from 2016 to 2021.
Compared clinical and microbiological features, treatment strategies, and mortality rates between patients with and without aortic root abscess.
17% of patients had an aortic root abscess.
Patients with abscesses were younger and more frequently male.
Patients with abscesses had higher 1-year mortality rates, especially those not undergoing surgery (55.4%).