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April 3, 2026Journal of Applied Oral Science0 citationsOpen Access

Can angiotensin II affect the inflammatory response of human dental pulp cells in vitro?

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BCBella Luna Colombini-IshikiriamaTDThiago José DionísioTGThais Francini Garbieri

Key Result

Angiotensin II has no influence on the expression of inflammatory mediators by human dental pulp fibroblasts in vitro.

Key Points

  • To investigate whether angiotensin II influences inflammatory responses in human dental pulp cells.
  • In vitro experimentation with human dental pulp fibroblasts
  • Assessment of inflammatory mediator expression under varying conditions
  • Use of control treatments for comparison
  • ANG-II does not affect the expression of inflammatory mediators
  • No significant changes observed in fibroblast response to ANG-II.

Structured PICO

Does angiotensin II affect the expression of inflammatory mediators in human dental pulp fibroblasts in vitro?

P
Population
human dental pulp fibroblasts in vitro
I
Intervention
angiotensin II
O
Outcome
expression of inflammatory mediatorssurrogate

Angiotensin II does not affect the inflammatory response of human dental pulp cells in vitro.

Abstract

These findings clearly show that ANG-II has no influence on the expression of inflammatory mediators by human dental pulp fibroblasts under the tested conditions.

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Cite This Study

Colombini-Ishikiriama et al. (2026) studied this question. Angiotensin II has no influence on the expression of inflammatory mediators by human dental pulp fibroblasts in vitro.

synapsesocial.com/papers/69cf588f5a333a82146097e2https://doi.org/10.1590/1678-7765-2025-0822
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