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April 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Lower Allele Frequency of TERT -rs2242652 in Sub-Saharan African Populations Compared With American Populations and Hepatocellular Carcinoma Risk

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PCPerapa ChotiprasidhiVUViviana P. Gonzalez UmpierreYNYvonne Ayerki Nartey

Key Points

  • To examine allele frequency differences of TERT-rs2242652 between sub-Saharan African and American populations and their relation to HCC risk.
  • Comparative analysis of allele frequencies between sub-Saharan Africans and European Americans
  • Assessment of hepatocellular carcinoma risk association with TERT-rs2242652 allele status
  • Investigation of multiethnic genetic variations
  • Lowest allele frequency of protective TERT-rs2242652 observed in sub-Saharan African populations
  • Significantly lower compared to European Americans
  • Implications for HCC prevention strategies in different populations

Abstract

In sub-Saharan African populations, there was a lower frequency of the HCC protective allele TERT-rs2242652 compared with European Americans. These findings underscore the importance of multiethnic genetic studies in understanding population differences in HCC risk and developing prevention strategies.

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Cite This Study

Chotiprasidhi et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ced5a333a821460a722https://doi.org/10.1200/go-25-00446
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