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April 3, 2026Phytotherapy Research

Glycyrrhizic Acid Alleviates Osimertinib‐Induced Cutaneous Toxicity by Inhibiting Keratinocyte Apoptosis and Inflammation

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Authors

CWCongying WangJLJiabin LuHFHuangxi Fu

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Overview

Demonstrates Glycyrrhizic Acid alleviates skin toxicity in mice treated with Osimertinib, suggesting a potential clinical benefit.

Key Points

  • This research investigates whether Glycyrrhizic Acid can reduce skin toxicity caused by Osimertinib in mice.
  • Administered 50 mg/kg/day Osimertinib to mice for 42 days
  • Evaluated keratinocyte apoptosis using PI/Annexin-V assay and western blotting
  • Measured expression levels of inflammatory factors like CCL2 and IL18
  • Treated mice with 30 mg/kg/day of Glycyrrhizic Acid
  • Glycyrrhizic Acid reduced the frequency and severity of cutaneous toxicity
  • Restored epidermal thickness in mice
  • Lowered DNA damage levels
  • Decreased inflammation markers after treatment

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d345a333a821460acf2https://doi.org/10.1002/ptr.70310
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