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April 3, 2026EMBO ReportsOpen Access

Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis

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Authors

LBLoïc BideauLBLoeiza BaduelGKGabriel Krasovec

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Overview

Investigates Notch signaling's role in neurogenesis in an annelid, indicating its importance in neurodevelopment.

Key Points

  • To explore the functions of Notch signaling during post-embryonic neurogenesis in the annelid Platynereis dumerilii.
  • Investigated expression of Notch pathway components during posterior elongation and regeneration.
  • Conducted chemical inhibitions of Notch signaling pathway.
  • Performed RNA sequencing to analyze gene expression changes.
  • Notch signaling regulates neural progenitor specification and differentiation.
  • Disruption of Notch activity results in defects in central nervous system organization.
  • Notch pathway functions are conserved across bilaterians, highlighting its evolutionary significance.

Cite This Study

Bideau et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e115a333a821460c3echttps://doi.org/10.1038/s44319-026-00731-6
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