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April 3, 2026Clinical and Translational Allergy0 citationsOpen Access

Associations Between Different Eosinophil Activity Markers and Clinical Outcomes in Young Asthmatics

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NJNils Oskar JõgiUppsala UniversityNTNikolaos TsolakisUppsala UniversityASAnders SjölanderThermo Fisher Scientific (Sweden)

Key Points

  • This research assesses the relationship between eosinophil activity markers and clinical outcomes in young asthmatics.
  • Evaluated associations between S-EDN, BEC, and FeNO in young asthmatics.
  • Analyzed clinical outcomes related to airway obstruction.
  • Identified potential implications for using S-EDN as a biomarker.
  • S-EDN showed promise as an alternative to BEC for assessing airway obstruction.
  • Combining S-EDN with FeNO and BEC yielded limited additional clinical value.
  • Further studies are necessary with larger cohorts to confirm these findings.

Abstract

S-EDN may serve as an alternative to BEC in research setting and could be relevant in assessing airway obstruction. However, adding S-EDN as a routine biomarker alongside FeNO and BEC may offer limited additional clinical value. Further research in larger cohorts is needed to validate these findings and establish optimal cut-offs.

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Cite This Study

Jõgi et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e2e5a333a821460c591https://doi.org/10.1002/clt2.70167
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Eosinophil-derived neurotoxin is an asthma biomarker linked to wheezing severity in preschool children2025
  2. 2Evaluation of Eosinophil-Derived Neurotoxin Level and Asthma Severity in Isolated Asthma in Comparison to Asthma with Allergic Comorbidity2024
  3. 3C34-22 Combined Blood (Eosinophils) and Airway (Fraction Exhaled Nitric Oxide (Feno)) Biomarkers Predict Asthma Severity and Control2026
  4. 4Urinary eosinophil‐derived neurotoxin is associated with reduced lung function in pediatric asthma2024 · 3 citations
  5. 5Non-endoscopic Biomarkers and Sampling for Diagnosis and Monitoring of Adult Eosinophilic Esophagitis: A Systematic Review and Pooled Analysis2025