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April 3, 2026Cancer Medicine0 citationsOpen Access

Significance of Early Proton Beam Therapy Initiation in Achieving Complete Response in Pediatric Medulloblastoma: A Retrospective Study

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ZSZhipeng ShenZHZhuo HouWHWei Han

Key Points

  • The aim is to assess how the timing of proton beam therapy influences treatment response in pediatric medulloblastoma patients.
  • Conducted a retrospective analysis of pediatric medulloblastoma cases
  • Examined time intervals between surgery and proton beam therapy initiation
  • Measured complete response rates following treatment
  • Patients receiving proton beam therapy within 31 days after surgery showed higher complete response rates
  • Shorter intervals between surgery and therapy positively affected early treatment outcomes

Abstract

This study highlights that the timely initiation of PBT following surgery, particularly within 31 days, is associated with improved CR in pediatric medulloblastoma. Our findings suggest that a shorter interval between surgery and PBT initiation may be an important factor influencing early treatment response, providing preliminary evidence to support earlier postoperative PBT delivery.

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Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e5f5a333a821460ca99https://doi.org/10.1002/cam4.71757
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